This is an educational list of interactions tied to a public source. It is not a complete medication review and it is not medical advice. Ask a pharmacist, or the clinician who prescribes the medicine, before you start, stop, or change a supplement. A pair that is missing here is not a safety clearance. SupplementScore takes no ads, sponsorships, or affiliate income. How this site is funded.
Berberine is sold as a blood-sugar supplement. In people with type 2 diabetes, a meta-analysis found that adding it to glucose-lowering drugs lowered blood sugar more than either one alone. That is a reason to tell the prescriber, not a reason to adjust a dose on your own.
The paper studied people with type 2 diabetes who were taking glucose-lowering drugs. It does not test every newer diabetes medicine, and it does not prove the combination is unsafe for every person.
Names people search: Metformin, insulin, glipizide, glyburide, glimepiride
Ask before you combine
Ask before you combine
Berberine plus diabetes drugs lowered blood sugar more than either alone
A 2019 systematic review and meta-analysis in Endocrine Journal (PMID 30393248) looked at berberine in people with type 2 diabetes. It found that berberine combined with glucose-lowering drugs reduced blood sugar more than either berberine or the drugs alone. A bigger drop is a reason the prescriber should know. Do not change an insulin or tablet dose to "make room" for berberine on your own. The paper does not test every newer diabetes drug.