Layered, evidence-tiered protocols for ten conditions
Each guide picks the supplements with actual trial evidence, names the doses the trials used, and is honest about which conditions have a strong evidence base and which mostly don't. No sponsorships, no affiliate links. None of these replace clinical care; the cautions in each article matter.
Mood, sleep, and stress
Hormonal & reproductive health
Neurological & cognitive
Chronic illness — honest about uncertainty
Gut & skin
IBS supplement protocol
Subtype-specific layers for IBS-D and IBS-C, the universal peppermint + psyllium foundation, and the strain-specific probiotic story.
Eczema supplement stack
Vitamin D, specific probiotic strains, modest omega-3 evidence — and the topical / biologic layer that matters more.
Acute / lifestyle
Recently added protocols
Hashimoto's thyroiditis supplement protocol — what selenium can and can't do
Selenium and vitamin D have real trial data on thyroid antibodies, but they're surrogate markers — and the levothyroxine absorption and biotin lab-interference issues matter more than any capsule. What to take, what to skip.
Gout supplement protocol — what actually lowers uric acid and prevents flares
Vitamin C and tart cherry have modest, mostly preventive evidence; neither replaces urate-lowering therapy. Plus the colchicine interactions that can turn dangerous.
Perimenopause supplement protocol — what helps hot flashes, sleep and bone
Soy isoflavones nudge hot flashes down; calcium and vitamin D matter because bone loss accelerates now. Black cohosh and omega-3 supplements mostly failed in good trials — and why St John's wort is the one to avoid.
ADHD supplement stack — what the controlled trials actually support
Omega-3, iron, zinc, magnesium, saffron — the supplements with controlled-trial evidence for ADHD symptoms. Doses, expected effect sizes, when not to use.
Chronic constipation — what works in what order
A layered, evidence-based protocol for chronic functional constipation — fiber, magnesium, kiwifruit, and the strain-specific probiotic story.
Chronic inflammation supplement protocol — what actually moves CRP and inflammatory markers
Chronic low-grade inflammation — the supplements with trial evidence on CRP, IL-6, and TNF-α: omega-3, curcumin, vitamin D in deficiency. And why diet and weight beat the supplement layer.
Dry eye supplement protocol — what omega-3 and the rest of the evidence shows
The supplements with trial evidence in dry eye disease — omega-3 EPA/DHA (with caveats from the DREAM trial), vitamin D, and the broader hydration and environment changes that dominate the supplement
Endometriosis supplement protocol — what the evidence actually shows
Endometriosis supplements — the small but real evidence for omega-3, NAC, curcumin, and vitamin D as pain and inflammation adjuncts. With the firm position that medical and surgical care lead.
Female fertility supplement protocol — what the trial evidence actually supports
Female fertility supplements — what the evidence supports: preconception folate, vitamin D, myo-inositol in PCOS, CoQ10 in older oocytes, and the supplements oversold to women trying to conceive.
Fibromyalgia supplement protocol — what has trial evidence
The supplements with the strongest evidence in fibromyalgia — vitamin D in deficient patients, magnesium, CoQ10, SAMe, and what to skip. Adjuncts to standard care, not a substitute.
GERD — what helps, what makes it worse
The narrow set of supplements with credible GERD evidence — alginates, DGL, melatonin — and the long list of supplements that make reflux worse.
Hypothyroidism — what to add, what to avoid
Selenium, vitamin D, iron status, and the absorption-interaction list that matters with levothyroxine. Plus the iodine question and what to skip.
IBS-D supplement protocol — peppermint, soluble fibre, and the specific probiotic strains with evidence
Diarrhea-predominant IBS — the supplements with trial evidence in IBS-D specifically: enteric-coated peppermint, soluble fibre (psyllium), and strain-specific probiotics. With the FODMAP and stress-ma
AMD supplement protocol — AREDS2 and the rest of the evidence
The supplements with trial evidence for age-related macular degeneration — the AREDS2 formulation, lutein/zeaxanthin, omega-3 — and what to skip. Adjuncts to ophthalmology care.
Male fertility supplement protocol — what improves sperm parameters
The supplements with trial evidence for male fertility — CoQ10, L-carnitine, zinc, folate, omega-3 — and the lifestyle factors that often dominate the supplement layer.
Menopausal hot flashes — supplement protocol with honest evidence grading
Hot flashes (vasomotor symptoms) in menopause — what the trial evidence shows for soy isoflavones, black cohosh, and the rest. Including why MHT and fezolinetant outperform supplements in moderate-sev
Metabolic syndrome — what supplements actually move the dial
The supplements with trial evidence in metabolic syndrome — psyllium, berberine, omega-3, magnesium, oat beta-glucan — and what to skip. An adjunct to weight loss and exercise, not a substitute.
Osteoporosis supplement stack — what actually preserves bone density
Calcium, vitamin D3, vitamin K2, magnesium, and protein — the supplement and nutrition foundation that complements (not replaces) prescription osteoporosis therapy.
Peripheral neuropathy supplement protocol — what has trial evidence
The supplements with trial evidence in peripheral neuropathy — alpha-lipoic acid, methylcobalamin, benfotiamine — and what to skip. Adjuncts to standard care, not substitutes.
Pre-diabetes — the supplements with credible glycaemic evidence
Berberine, inositol, alpha-lipoic acid, soluble fiber — the supplements with credible glycaemic evidence in pre-diabetes, plus the lifestyle layer that matters more.
Restless legs syndrome — what supplements actually have evidence
The supplements with real evidence in restless legs syndrome — iron repletion (the single most important intervention if ferritin is low), magnesium, vitamin D, and what to skip.
Adult acne — supplement adjuncts to dermatological care
Adult acne — supplement adjuncts (zinc, omega-3, low-GI diet support) used alongside topical retinoids, BPO, and oral therapies. What the trial evidence actually shows.
Atrial fibrillation — supplement protocol with critical safety caveats
Atrial fibrillation — supplement adjuncts (magnesium, potassium, the omega-3 paradox) with critical safety caveats around anticoagulation and AFib-triggering supplements.
Dysmenorrhea — supplement protocol with surprisingly strong RCT base
Primary dysmenorrhea (period pain) — supplement stack (magnesium, omega-3, ginger, vitamin B1, vitamin E) with surprisingly strong RCT support for non-NSAID adjunct relief.
Psoriasis — supplement adjuncts to dermatological care
Psoriasis — supplement adjuncts (vitamin D, omega-3, curcumin) used alongside topical, phototherapy, and biologic care. What the trials show and what to skip.
Sarcopenia — supplement protocol for age-related muscle loss
Sarcopenia — supplement stack (whey/leucine, creatine, vitamin D, HMB, omega-3) for prevention and reversal of age-related muscle loss. Paired with resistance training.
Age-related cognitive decline — supplement evidence in older adults
Age-related cognitive decline / mild cognitive impairment — supplement evidence (B-vitamins/VITACOG, omega-3, citicoline, vitamin D) and what doesn
Iron deficiency anemia — the evidence-based oral repletion strategy
Iron deficiency anemia — alternate-day oral iron is the modern evidence-based approach. Bisglycinate vs sulfate, what to avoid, when IV iron is right.
Premenstrual Dysphoric Disorder (PMDD) — adjunct supplements alongside medical care
Premenstrual Dysphoric Disorder (PMDD) — supplement adjuncts to SSRI / OCP treatment. The medical mainstays dominate; supplements have a narrow role.
Premenstrual Syndrome (PMS) — the supplement evidence
Premenstrual syndrome (PMS) — supplement stack: calcium, chasteberry (Vitex), B6, magnesium, saffron. Trial-backed picks and what to skip.
Seasonal Affective Disorder — what supplements can adjunct to light therapy
Seasonal Affective Disorder (SAD) — supplement adjuncts to light therapy: vitamin D, omega-3, SAMe, melatonin timing. What dominates outcomes.
Crohn's disease — supplements that address the malabsorption layer
Vitamin D, B12, iron, and the malabsorption layer that matters in Crohn
High cholesterol — what to add, what to avoid
Soluble fiber, plant sterols, bergamot, and the niacin question for LDL and triglycerides. Plus the red yeast rice warning and what to skip.
Knee osteoarthritis — what to add, what to avoid
Curcumin, Boswellia, collagen peptides, and the glucosamine question — what 30 years of trials actually show for knee osteoarthritis pain and function.
IBS-C protocol — what supplements actually move stool in constipation-predominant IBS
Supplement protocol for IBS-C (constipation-predominant IBS) — magnesium oxide, soluble fibre (PHGG, psyllium), kiwifruit, and the probiotic strains with trial evidence in IBS-C specifically.
Type 2 diabetes — what actually moves HbA1c
Berberine, soluble fibre, magnesium, alpha-lipoic acid, vitamin D — the supplements with credible RCT evidence on HbA1c and insulin resistance in T2DM, with the medication-interaction layer that matters.
Mild-to-moderate depression — adjunctive supplements with real evidence
Saffron, EPA-dominant omega-3, SAMe, L-methylfolate, vitamin D — supplements with credible RCT evidence as adjuncts to therapy and antidepressant care. With the SSRI / MAOI interaction layer that matters.
Peptic ulcer disease — what supports mucosal healing
Mastic gum, zinc-carnosine, DGL, probiotics, broccoli sprout sulforaphane, vitamin C — supplements with credible evidence for ulcer healing and H. pylori eradication support alongside PPIs and antibiotics.
COPD adjunct — what reduces exacerbations
High-dose NAC, vitamin D in deficiency, omega-3, magnesium, vitamin C, creatine — supplements with credible RCT evidence for COPD as adjuncts to bronchodilators, inhaled corticosteroids, and pulmonary rehab.
Cataract prevention — what supplements actually slow lens opacity progression
Cataract prevention supplement protocol — what the AREDS-era and post-AREDS trials show on lutein, zeaxanthin, vitamin C, vitamin E, and where lifestyle outperforms.
Neuropathic pain — supplement stack and where the evidence is real
Neuropathic pain supplement stack — alpha-lipoic acid, acetyl-L-carnitine, methylcobalamin, palmitoylethanolamide. Where the trial evidence is genuine and how to layer alongside guideline pharmacother
Tendinopathy — supplement protocol and what actually heals tendons
Tendinopathy supplement protocol — collagen with vitamin C, omega-3, glucose loading timing, and why progressive heavy slow resistance dwarfs any supplement effect.
Statin Myopathy — supplement protocol for SAMS
Statin-associated muscle symptoms — supplement protocol with CoQ10, vitamin D, L-carnitine, and what the trial record actually shows.
Menstrual migraine — what supplements actually have evidence
Menstrual and menstrually-related migraine — magnesium, riboflavin, CoQ10, and the cycle-specific timing protocols with real evidence.
Kidney stone prevention — what the controlled trials actually support
Kidney stone prevention — what the trial evidence actually supports: potassium citrate, magnesium, hydration, and what to skip. Stone-type-specific guidance.
More condition deep-dives are queued. Have a condition you'd like covered? Open a request via the about page contact and we'll add it to the editorial queue.
Condition protocols
Evidence-based supplement protocols for specific health conditions.
- ADHD supplement stack — what the controlled trials actually support
- Adult acne — supplement protocol adjunct to dermatological care
- Age-related cognitive decline — the supplement evidence in older adults
- The 2026 anxiety supplement stack — a layered, evidence-based protocol
- Atrial fibrillation — supplement protocol with safety caveats
- BPH protocol — saw palmetto, beta-sitosterol, pygeum, and what actually moves IPSS
- Cataract prevention — what supplements actually slow lens opacity progression
- Chronic constipation supplement protocol — what works in what order
- Chronic inflammation supplement protocol — what actually moves CRP and inflammatory markers
- Cold sores / recurrent HSV-1 — what L-lysine, lemon balm, and zinc actually do
- COPD adjunct supplement protocol — what reduces exacerbations
- Crohn's disease — supplements that address the malabsorption layer
- Mild-to-moderate depression — adjunctive supplements with credible RCT evidence
- Dry eye supplement protocol — what omega-3 and the rest of the evidence shows
- Dysmenorrhea (period pain) — supplement protocol with strong RCT base
- Eczema (atopic dermatitis) supplement stack — what helps, what doesn't
- Endometriosis supplement protocol — what the evidence actually shows
- Female fertility supplement protocol — what the trial evidence actually supports
- Fibromyalgia supplement protocol — what has trial evidence
- Functional dyspepsia supplement protocol — what the trial evidence supports
- GERD supplement protocol — what helps, what makes it worse
- Gout supplement protocol — what actually lowers uric acid and prevents flares
- Hashimoto's thyroiditis supplement protocol — what selenium can and can't do
- High cholesterol — what to add, what to avoid
- Hypothyroidism supplement stack — what to add, what to avoid
- IBS-C protocol — what supplements actually move stool in constipation-predominant IBS
- IBS-D supplement protocol — peppermint, soluble fibre, and the specific probiotic strains with evidence
- IBS supplement protocol — by subtype, with the evidence behind each layer
- Insomnia supplement protocol — what works beyond melatonin
- Iron deficiency anemia — supplementation strategy that actually works
- AMD supplement protocol — AREDS2 and the rest of the evidence
- Male fertility supplement protocol — what improves sperm parameters
- Menopausal hot flashes — supplement protocol with honest evidence grading
- Menstrual migraine — what supplements actually have evidence
- Metabolic syndrome — what supplements actually move the dial
- Migraine prevention stack — the four supplements with guideline-level evidence
- Multiple sclerosis supplement adjunct — vitamin D, biotin, omega-3, and what the trials actually show
- NAFLD / fatty liver — supplement evidence and protocol
- Neuropathic pain — supplement stack and where the evidence is real
- Knee osteoarthritis — what to add, what to avoid
- Osteoporosis supplement stack — what actually preserves bone density
- PCOS supplement protocol — what the 2025 evidence supports
- Perimenopause supplement protocol — what helps hot flashes, sleep and bone
- Peptic ulcer disease supplement protocol — what supports mucosal healing
- Peripheral neuropathy supplement protocol — what has trial evidence
- Pre-diabetes supplement protocol — the four with metformin-comparable evidence
- Premenstrual Dysphoric Disorder (PMDD) — what supplements can adjunct to SSRIs
- Premenstrual Syndrome (PMS) — supplement stack with trial evidence
- Psoriasis — supplement adjuncts to dermatological care
- Recurrent UTI prevention — what the supplement evidence supports
- Restless legs syndrome — what supplements actually have evidence
- Sarcopenia — supplement protocol for muscle loss prevention in older adults
- Seasonal Affective Disorder — supplement adjuncts to light therapy
- SIBO protocol — what supplements actually help small intestinal bacterial overgrowth
- Statin Myopathy — supplement protocol for SAMS
- Tendinopathy — supplement protocol and what actually heals tendons
- Type 2 diabetes supplement protocol — what actually moves HbA1c