Layered, evidence-tiered protocols for ten conditions
Each guide picks the supplements with actual trial evidence, names the doses the trials used, and is honest about which conditions have a strong evidence base and which mostly don't. No sponsorships, no affiliate links. None of these replace clinical care; the cautions in each article matter.
Mood, sleep, and stress
Hormonal & reproductive health
PCOS supplement protocol — the 2025 evidence
Inositol, vitamin D, berberine, spearmint — the four supplements with the strongest PCOS evidence, and the multi-ingredient products to skip.
Perimenopause hot-flash protocol
Black cohosh, soy isoflavones, S-equol, and the sleep / bone layer. Honest framing of where hormone therapy still wins.
Prostate health supplement protocol
Standardised saw palmetto, beta-sitosterol, pygeum — with honest framing of the SELECT trial and what it means for prevention claims.
Neurological & cognitive
Chronic illness — honest about uncertainty
Long COVID supplement evidence — what the 2025 trials actually show
A careful read of the trial literature. Where there's signal (CoQ10, omega-3, B12 in deficient patients), where there isn't, and what to skip.
ME-CFS supplement evidence
The narrow set of supplements with even small RCT signal in chronic fatigue, plus the framing of pacing and energy management that matters more.
Gut & skin
IBS supplement protocol
Subtype-specific layers for IBS-D and IBS-C, the universal peppermint + psyllium foundation, and the strain-specific probiotic story.
Eczema supplement stack
Vitamin D, specific probiotic strains, modest omega-3 evidence — and the topical / biologic layer that matters more.
Renal & hepatic
Chronic kidney disease — what to add, what to avoid
The narrow set of supplements with credible CKD-supportive evidence — and the much longer list of what worsens kidney function or accumulates dangerously in renal impairment.
NAFLD supplement protocol
Vitamin E, omega-3, milk thistle — and the lifestyle layer (7–10% body weight loss, Mediterranean pattern) that out-performs every supplement.
Gallstone prevention
Vitamin C, ursodeoxycholic acid for the rapid-weight-loss window, and a clear no on the popular "olive oil flush" protocols.
Infection & allergy
Recurrent UTI prevention
D-mannose at 2 g/day and PAC-standardised cranberry (≥36 mg PAC/day) — the two compounds that genuinely work, plus where vaginal estrogen out-performs both.
Allergic rhinitis protocol
Quercetin, butterbur (PA-free only), vitamin D — and the saline-irrigation and intranasal-steroid layer that out-performs the supplement aisle.
More condition deep-dives are queued. Have a condition you'd like covered? Open a request via the about page contact and we'll add it to the editorial queue.