Yohimbine HCl

Tier 3 — weak evidence · Fat loss · Stimulant · Alpha-2 antagonist

The purified HCl salt of yohimbine, the alpha-2 adrenergic antagonist from Pausinystalia yohimbe bark. By blocking inhibitory alpha-2 receptors on fat cells, yohimbine increases norepinephrine release and fat mobilisation, particularly from stubborn adipose depots. RCTs confirm acute and chronic fat loss, especially during fasted exercise. Purified HCl allows precise dosing unlike whole bark extracts. Contraindicated in anxiety disorders, hypertension, cardiac arrhythmia, and alongside other stimulants.

Dose: 2.5–20 mg/day fasted, starting at 2.5 mg and increasing slowly