Vitamin B6 (P5P)

Tier 2 — promising · PMS · Pregnancy nausea · OCP support

Effective for PMS symptoms and pregnancy nausea. A 2024 review confirmed significant PMS relief. FDA/ACOG recommend it for pregnancy nausea at 10–25 mg three times daily. Oral contraceptives deplete B6 levels. Use the active P5P form for better absorption and tolerability. Critical warning: doses above 100 mg/day long-term cause irreversible peripheral neuropathy (nerve damage).

Dose: 25–50 mg/day P5P for PMS/OCP support. 10–25 mg × 3 daily for pregnancy nausea. NEVER exceed 100 mg/day long-term.