TTFD / Allithiamine (fat-soluble B1)

Tier 2 — promising · Fat-soluble thiamine · Neurological · Dysautonomia · Blood-brain barrier

Thiamine tetrahydrofurfuryl disulfide (TTFD) is a fat-soluble thiamine derivative that readily crosses the blood-brain barrier and cell membranes, achieving intracellular concentrations far exceeding water-soluble thiamine HCl at equivalent doses. Synthesised in Japan for thiamine-dependent conditions, it is used in functional medicine for dysautonomia, POTS, chronic fatigue, Wernicke's encephalopathy, and conditions where standard thiamine fails to normalise function. Small case series and clinical observations show improvements in fatigue and autonomic symptoms. Evidence base relies…

Dose: 25–100 mg/day TTFD; start at 25 mg and titrate slowly; some neurological protocols use 100–300 mg/day under supervision