S-Adenosylmethionine (SAMe)

Tier 2 — promising · Depression · Joint · Liver

A natural compound your body makes that supports mood, joint health, and liver function. Multiple reviews found SAMe performs as well as older antidepressants for depression and also reduces arthritis pain. Warning: can trigger serotonin syndrome if combined with antidepressants — must not combine with SSRIs or MAOIs. Must use enteric-coated form.

Dose: 800–1,600 mg/day in divided doses on empty stomach; enteric-coated form required; AVOID with SSRIs/MAOIs