Resveratrol

Tier 3 — weak evidence · Anti-aging / Cardiovascular

One of the most hyped supplements of the past two decades, but resveratrol has failed to deliver in human trials. Only about 1% of the oral dose reaches the bloodstream, and even at higher doses no consistent clinical benefits have been found. Red wine provides tiny amounts with no proven benefit at those levels. The excitement came from animal studies that simply did not translate to humans.

Dose: No evidence-based dose — consistent null results in human trials; absorption problem makes standard doses ineffective