Resolvins / SPMs (Specialised Pro-resolving Mediators)

Tier 3 — weak evidence · Inflammation resolution · Recovery

Derived from omega-3 fatty acids, these molecules actively resolve inflammation rather than just suppressing it, representing a newer approach to managing inflammation. 2024 trials found SPM supplements significantly reduce post-exercise inflammation. Still an emerging area of research with no established standard dosing. Generally well tolerated.

Dose: 500–1,000 mg/day SPM-enriched fish oil; emerging evidence — standard dosing not established