Reishi (Ganoderma lucidum)

Tier 3 — weak evidence · Immunity · Sleep · Adaptogen

A traditional medicinal mushroom with confirmed immune-modulating effects in lab studies. In humans, evidence is limited to improved quality of life alongside cancer treatment. Sleep and stress-relief claims lack rigorous trial support. Requires dual extraction (hot water plus alcohol) to release active compounds. Generally safe for most people.

Dose: 1,000–3,000 mg/day dual-extracted (hot water + alcohol) fruiting body