PQQ (Pyrroloquinoline quinone)

Tier 3 — weak evidence · Mitochondria · Cognition · Energy

Stimulates your cells to produce new energy-generating mitochondria, which may help combat age-related energy decline. Small trials show improved sleep quality and reduced fatigue. A 2024 trial found improved mental flexibility in older adults. Often combined with CoQ10 for synergistic effects. Generally safe, though long-term data is still limited.

Dose: 10–20 mg/day with food; often combined with CoQ10