Palmitoyl tripeptide-1 (matrixyl, oral)

Tier 3 — weak evidence · Skin anti-aging · Collagen · Peptide

A synthetic peptide with proven topical anti-wrinkle effects (marketed as Matrixyl). Oral forms are being sold as anti-aging supplements but have zero evidence for oral bioavailability — peptides are digested in the stomach. Topical use is well-supported by dermatology research. Oral supplements are likely ineffective since the peptide would be broken down before reaching the skin.

Dose: Topical: proven effective in creams at 3–5%; oral supplements: no evidence of bioavailability — likely ineffective