Mucuna pruriens

Tier 3 — weak evidence · Dopamine · Testosterone · Mood

Naturally contains L-DOPA (3 to 6%), which is a direct precursor to the brain chemical dopamine. A 2024 trial showed improved sperm quality and testosterone in infertile men. Warning: interacts dangerously with Parkinson's medications and certain antidepressants. Should only be used under medical supervision due to its potent dopamine effects.

Dose: 300–600 mg/day standardised extract (15–20% L-DOPA); AVOID with levodopa or MAOIs