Methyl B12 + Methylfolate combo

Tier 3 — weak evidence · MTHFR · Methylation · Energy

Marketed to people with the MTHFR gene variant, which about 40% of the population carries. NIH notes most carriers have perfectly normal folate metabolism and do not need special supplements. Only clinically needed when blood tests actually show low folate, low B12, or elevated homocysteine levels. Safe but usually unnecessary for healthy people.

Dose: 1,000 mcg methyl-B12 + 400 mcg 5-MTHF/day; test homocysteine and serum levels first