Magnafolate (calcium L-methylfolate)

Tier 3 — weak evidence · Active folate · MTHFR · Methylation

A patented stable crystalline form of L-5-methyltetrahydrofolate, distinct from Quatrefolic (a glucosamine salt of the same active folate). Both deliver pre-converted active folate that bypasses the MTHFR enzyme step. Especially relevant for the ~30% of the population with reduced-activity MTHFR variants. Equivalent in effect to Quatrefolic; choice between the two is largely about supply and price.

Dose: 400–1,000 mcg L-methylfolate daily