Limosilactobacillus reuteri DSM 17938

Tier 2 — promising · Infant colic · Gut health · Bone density

L. reuteri DSM 17938 has the strongest evidence of any probiotic for infantile colic. Vaz 2023 meta-analysis (PMID 37962097) of 15 probiotics found DSM 17938 specifically reduced crying by 64.66 minutes per day (p=0.03) in breastfed infants, with greater benefit than other strains. Gutierrez-Castellon 2017 network meta-analysis (32 RCTs, N=2,242, PMID 29390535) found DSM 17938 superior to all other interventions (WMD −51.3 min/day vs control). Zermiani 2021 (10 trials, PMID 34627993) confirmed significant crying time reduction in breastfed infants week by week. Also shown to improve…

Dose: 100 million CFU/day (5 drops of the commercial preparation, e.g. BioGaia) for infant colic. For adult functional constipation, 10^8–10^9 CFU/day. Give for a minimum of 21–28 days.