Lactobacillus helveticus/B. longum R0052/R0175

Tier 2 — promising · Gut-brain axis · Stress · Mood

A specific probiotic combination (marketed as Cerebiome) with clinical evidence for the gut-brain axis. The landmark Messaoudi 2011 RCT (Br J Nutr) found this combination significantly reduced cortisol and psychological distress scores compared to placebo. Later trials (Kazemi 2019, Chahwan 2019) tested similar combinations in depression with more mixed results. One of the few probiotics with direct — if still modest — evidence for mood outcomes in adults.

Dose: 3 billion CFU/day of the R0052/R0175 combination; specific strains matter — generic alternatives are unproven