Lactase enzyme

Tier 2 — promising · Lactose intolerance · Dairy digestion

Provides exogenous beta-galactosidase to hydrolyse lactose in dairy food before it reaches the colon, preventing osmotic diarrhoea, bloating, and cramping in lactase-deficient individuals. Mechanism is well understood and effect is immediate — onset depends on enzyme being present in the gut at the same time as lactose. The 2024 Kozlowska-Jalowska systematic review of lactase in infant colic (5 RCTs, N=391, PMID 38426798) found inconclusive evidence for that specific indication; however, the well-established evidence for managing lactose intolerance symptoms in diagnosed adults and…

Dose: 6,000–9,000 FCC lactase units at the very first bite of dairy; increase to 18,000+ FCC for large dairy portions; infant drops per product instructions