Kaempferol

Tier 2 — promising · Flavonoid · Autophagy · Senolytic · Anti-inflammatory · Longevity

A flavonol found in kale, broccoli, capers, apples, and green tea that activates autophagy (cellular cleanup impaired in aging), inhibits NF-κB, STAT3, and PI3K signalling, and exhibits senolytic activity (selectively killing aged senescent cells) in cell culture. Epidemiological studies consistently associate higher dietary kaempferol with reduced colorectal, pancreatic, and lung cancer risk. Human clinical data for supplements is extremely limited — a 2023 pilot trial found kaempferol modestly improved insulin sensitivity markers. Most evidence is from in vitro, animal, and…

Dose: 25–100 mg/day standardised kaempferol supplement; prioritise dietary sources over supplements