Jimsonweed (Datura stramonium)

Tier 4 — risky / avoid · Anticholinergic · Delirium · Fatal

Contains the same anticholinergic alkaloids as belladonna at variable, unpredictable concentrations. Causes violent delirium, hyperthermia, seizures, and death. EDs regularly treat jimsonweed poisonings, especially in teenagers. Effects last 24–48 hours. No safe recreational or medicinal dose exists.

Dose: AVOID — unpredictable alkaloid content; causes prolonged delirium, hyperthermia, and death