Japanese knotweed (Reynoutria japonica)

Tier 3 — weak evidence · Resveratrol source · Lyme protocol · Anti-inflammatory

The most concentrated natural source of trans-resveratrol, providing far more per gram than red wine or grapes. Widely used in naturopathic Lyme disease protocols based on Stephen Buhner's work, though no clinical trials validate this use. Contains emodin, which has laxative effects at higher doses. May interact with blood thinners. The invasive plant species is sustainably harvested for supplements.

Dose: 500–1,000 mg/day root extract (standardised to resveratrol); Lyme protocol use is not clinically validated