Hericium erinaceus mycelium (Amyloban 3399)

Tier 3 — weak evidence · Neuroprotection · Mood · Cognitive decline

Unlike fruiting body extracts, the mycelium-derived product Amyloban 3399 standardises amycenone, a unique compound found only in the mycelial stage. Small Japanese trials found it improved cognitive function and reduced depression in patients with mild cognitive impairment. Different active compounds from fruiting body products. Limited evidence but a distinct product from standard lion's mane supplements.

Dose: 500–1,500 mg/day Amyloban 3399 standardised to amycenone; different active profile from fruiting body extracts