GlyNAC (Glycine + NAC)

Tier 2 — promising · Aging · Glutathione · Mitochondria

A combination of glycine and N-acetyl cysteine designed to replenish glutathione, which declines significantly with age. The Baylor group (Kumar et al. 2021 Clin Transl Med pilot, n=8, and 2023 J Gerontol A RCT, n=24, 16 weeks) reported GlyNAC improved glutathione levels, mitochondrial function, insulin resistance, and walking speed in older adults — promising but small studies requiring independent replication. One of the more promising anti-aging interventions with human trial data, though still early stage.

Dose: Glycine 1.33 mmol/kg/day + NAC 0.81 mmol/kg/day (~100 mg/kg each); typically 7 g glycine + 6 g NAC daily