Ginger (Zingiber officinale)

Tier 1 — strong evidence · Nausea · Inflammation · Pain

Ginger's bioactive gingerols and shogaols inhibit 5-HT3 receptors and act on COX/5-LOX pathways, producing antiemetic and anti-inflammatory effects. For nausea and vomiting in pregnancy, ACOG and multiple guidelines support 1 g/day as first-line non-pharmacological treatment. The 2023 Tan meta-analysis (33 RCTs, PMID 36969661) confirms ginger significantly outperforms placebo for nausea severity in pregnancy (moderate-quality evidence) and is comparable in effect to standard antiemetics. For postoperative nausea, the 2021 Lu meta-analysis (14 RCTs, N=1,506, PMID 34700257) confirms…

Dose: Pregnancy nausea: 250 mg × 4 times daily (1 g/day), standardised extract; general nausea: 500–1,000 mg at onset; anti-inflammatory: 500 mg × 2–3 daily; maximum 4 g/day