Emodin

Tier 3 — weak evidence · Gut motility · Anti-inflammatory

A naturally occurring anthraquinone found in rhubarb, aloe, and cascara with laxative and anti-inflammatory properties. Animal studies suggest benefits for gut inflammation and metabolic health, but human RCT evidence is essentially absent. Can cause diarrhoea, cramping, and electrolyte imbalances at higher doses. Long-term anthraquinone laxative use risks dependency and colonic changes.

Dose: 20–50 mg/day emodin; use short-term only; laxative dependency risk with prolonged use