DMG (Dimethylglycine)

Tier 2 — promising · Methyl donor · Performance · Immune

A tertiary amine derivative of glycine marketed for athletic performance, immune support, and autism. Once known as 'vitamin B15' or 'pangamic acid' (a misnomer — it is neither a vitamin nor pangamic acid). Serves as a methyl donor and is an intermediate in the conversion of betaine to glycine. Small human trials show equivocal results for performance; autism studies are underpowered. Broadly very safe and well-tolerated. Best viewed as a mild methylation adjunct with modest standalone evidence.

Dose: 125–500 mg 1–3 times daily