Diosmin

Tier 2 — promising · Varicose veins · Hemorrhoids · Venous insufficiency

A flavonoid prescribed across Europe for chronic venous insufficiency and hemorrhoids. Multiple large trials show it significantly reduces leg heaviness, swelling, and pain from varicose veins. The micronized form (MPFF, as in Daflon) has the strongest evidence. Also effective for acute hemorrhoid flares at higher doses. Very well tolerated with minimal side effects in clinical use.

Dose: 500 mg × 2 daily (micronized); 1,000 mg × 3 daily for 4 days then 1,000 mg × 2 for acute hemorrhoids