Dihydromyricetin (DHM)

Tier 2 — promising · Hangover · Liver protection · Alcohol metabolism

A flavonoid from the Japanese raisin tree that has been proposed to accelerate alcohol metabolism. Small human trials (e.g. Chen 2020 at 300 mg) have been mostly negative or inconsistent for hangover severity, while animal and mechanistic work suggest upregulation of liver ADH and ALDH enzymes and possible liver-protective effects. Generally well tolerated short-term. Does not reduce acute impairment. Human evidence for hangover prevention remains weak.

Dose: 300–600 mg before or during alcohol consumption; 600 mg studied in clinical trials