Cranberry PAC (A-type proanthocyanidins)

Tier 2 — promising · UTI prevention · Urinary tract · Women's health

Cranberry's A-type proanthocyanidins (PACs) inhibit P-fimbriated E. coli from adhering to the urothelial wall, potentially reducing UTI recurrence without antibiotic resistance. The 2023 Cochrane review (50 RCTs, 8,857 participants, PMID 37947276) confirms cranberry products reduce the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs (RR 0.74, moderate certainty), in children (RR 0.46), and in people susceptible after interventions (RR 0.47). Benefits were not demonstrated in elderly institutionalised individuals, pregnant women, or those with bladder-emptying…

Dose: 36 mg/day A-type proanthocyanidins from standardised cranberry extract; verify label claims — most supplements are significantly underdosed