Coleus forskohlii (Forskolin)

Tier 2 — promising · cAMP · Thyroid · Weight

Forskolin activates adenylate cyclase, raising cyclic AMP in cells. A few small trials suggest benefits for body composition in overweight men and reduced intraocular pressure in glaucoma. Weight loss evidence is limited to 1–2 small-sample trials. Can lower blood pressure and may interact with antihypertensives and anticoagulants. Use cautiously with these medications.

Dose: 250 mg of 10% forskolin extract twice daily; limited evidence for weight loss