Chromium picolinate

Tier 3 — weak evidence · Insulin sensitivity · Glucose · Weight

Most Americans aren't deficient in chromium, which limits the usefulness of supplements. A 2024 review found only a modest blood sugar reduction in diabetics already on medication. European food safety authorities have approved no health claims. May be worth trying if you have confirmed chromium deficiency, but otherwise offers little benefit.

Dose: 200–1,000 mcg/day; evidence weak in non-deficient healthy adults