Chromium nicotinate (polynicotinate)

Tier 3 — weak evidence · Chromium form · Glucose · Metabolic

Chromium bound to niacin rather than picolinic acid, retaining chromium's glucose/insulin effects while avoiding theoretical picolinate concerns around oxidative DNA damage seen in some in-vitro work. Polynicotinate has similar absorption to picolinate but may be more stable in gut. Evidence for glycaemic benefit is modest at best in people without clear chromium deficiency. A reasonable alternative form for those worried about picolinate or already taking niacin. Avoid above 1000 mcg/day chronically.

Dose: 100–400 mcg elemental chromium as polynicotinate daily