Cat's claw (Uncaria tomentosa)

Tier 3 — weak evidence · Immunity · Inflammation · Arthritis

A South American vine used traditionally for inflammation and immunity for centuries. Small trials show modest anti-inflammatory effects in osteoarthritis, but study quality is low and sample sizes are small. May interact with blood thinners and immunosuppressant medications. Not recommended for people with autoimmune conditions without medical guidance.

Dose: 250–350 mg/day standardised extract; avoid with anticoagulants or immunosuppressants