Boswellic acids AKBA (standardised)

Tier 2 — promising · Joint pain · IBD · 5-LOX inhibitor

The most potent fraction of Boswellia serrata, acetyl-11-keto-beta-boswellic acid (AKBA), specifically inhibits 5-LOX inflammation without affecting COX pathways. A 2025 review ranked Boswellia first among natural joint supplements for knee osteoarthritis pain. Higher AKBA content distinguishes premium from low-quality extracts. Better tolerated than NSAIDs with no GI bleeding risk.

Dose: 100–300 mg/day AKBA (look for extracts standardised to 30% AKBA); take with a fat-containing meal