Betaine TMG (trimethylglycine)

Tier 2 — promising · Methylation · Homocysteine · Liver

A methyl donor that helps your body convert homocysteine back to methionine, reducing cardiovascular risk. FDA-approved for the rare condition homocystinuria, and effective for lowering elevated homocysteine in the general population. Also supports liver health by preventing fat accumulation. Found naturally in beets and spinach. Very safe at recommended doses with decades of clinical use for homocystinuria.

Dose: 500–3,000 mg/day; 6,000 mg/day for elevated homocysteine under medical supervision