Bergamot citrus polyphenol extract

Tier 2 — promising · LDL cholesterol · Triglycerides · Blood sugar · Statin-like · BGE

The peel of bergamot oranges (Citrus bergamia, grown only in Calabria, Italy) is uniquely rich in polyphenols including brutieridin and melitidin, which inhibit HMG-CoA reductase (same target as statins) and PCSK9. The Mollace group in Italy has published multiple RCTs (from 2010 onwards) reporting 500–1,000 mg/day reduced LDL by roughly 24–36%, triglycerides by 30–39%, and improved fasting glucose over 30–180 days. The Huang 2021 Nutrients meta-analysis (12 trials) confirmed significant reductions in total and LDL cholesterol, though effect sizes were smaller than the Mollace…

Dose: 500–1,000 mg/day standardised Bergamot Polyphenol Fraction (BPF, 35–40% polyphenols); taken with meals