Berberis aristata (Indian barberry)

Tier 3 — weak evidence · Ayurveda · Glucose · Eye health

The traditional Ayurvedic source of berberine, known as Daruharidra. Contains additional alkaloids including palmatine and jatrorrhizine that may enhance the metabolic effects of berberine. A 2024 RCT found 500 mg twice daily significantly improved HbA1c in type 2 diabetes. Also used traditionally for eye infections and as a bitter digestive tonic. Same drug interaction profile as berberine.

Dose: 500–1,000 mg/day standardised root extract; equivalent berberine content to Coptis-derived supplements