Barberry (Berberis vulgaris)

Tier 3 — weak evidence · Berberine source · Gut · Antimicrobial

A natural source of berberine at lower concentrations than purified berberine supplements. Traditionally used across the Middle East and Europe for digestive and liver complaints. The whole plant extract provides additional alkaloids beyond berberine that may contribute to effects. Less studied than purified berberine. Shares the same drug interaction profile as berberine supplements.

Dose: 500–1,500 mg/day bark or root extract; provides berberine plus other alkaloids; same interactions as berberine