Apigenin

Tier 3 — weak evidence · Sleep · Anxiety · Neuroprotection

A compound found in chamomile that gently activates the brain's calming receptors. Provides mild anxiety relief without drowsiness or dependency. Also helps preserve NAD+, a molecule linked to aging. Human trial data is still limited, but the safety profile is excellent. Chamomile extract standardized for apigenin is the preferred form.

Dose: 50–100 mg/day; chamomile extract standardised to apigenin preferred