Adenosylcobalamin (dibencozide)

Tier 2 — promising · Vitamin B12 · Mitochondrial · Energy

One of two active coenzyme forms of vitamin B12 (the other being methylcobalamin). Adenosylcobalamin is the mitochondrial form required by methylmalonyl-CoA mutase — critical for branched-chain amino acid, odd-chain fatty acid, and cholesterol metabolism. While methylcobalamin supports methylation/CNS, adenosylcobalamin supports cellular energy and is uniquely suited for those with elevated methylmalonic acid. Combined hydroxo/methyl/adenosyl products offer the broadest coverage.

Dose: 1000–5000 mcg adenosylcobalamin (dibencozide) daily, or combined with methylcobalamin