Medication × supplement interactions
When you take a prescription medication, the next question is usually what supplements interact with it. Each page lists supplements to avoid, take with caution, simply monitor, and ones that may complement the medication. PMIDs cited; not medical advice — always discuss any supplement change with a qualified clinician.
Amlodipine and supplements: interactions, cautions, and safe stacks
Amlodipine and supplements: which to avoid (St John's wort), which to watch (grapefruit, hawthorn, berberine, piperine), and which are safe or supportive (magnesium, CoQ10). Independent,…
Gabapentin and supplements: interactions, cautions, and safe stacks
Gabapentin and supplements: divalent-cation chelation (magnesium, calcium, iron), additive CNS sedation (kava, valerian, CBD), and why most CYP-modulating supplements actually don't matter here.…
Semaglutide and supplements: interactions, cautions, and safe stacks
Semaglutide and supplements: delayed gastric emptying changes how everything is absorbed, and rapid weight loss creates real micronutrient and lean-mass concerns. Which supplements actually help…
Sertraline and supplements: interactions, cautions, and safe stacks
Sertraline and supplements: which serotonergic supplements to avoid (5-HTP, L-tryptophan, SAMe, St John's wort), which to discuss with a psychiatrist (saffron, rhodiola), and what's actually safe…
Tramadol and supplements: interactions, cautions, and safe stacks
Tramadol's dual opioid+SNRI mechanism makes serotonergic and sedative supplements especially dangerous. Why 5-HTP, L-tryptophan, SAMe, St John's wort, saffron, rhodiola, kratom, and kava deserve…
Bupropion and supplements: interactions, cautions, and safe stacks
Bupropion (Wellbutrin, Zyban) and supplements: what to avoid (St John
Fluoxetine and supplements: interactions, cautions, and safe stacks
Fluoxetine (Prozac, Sarafem) and supplements: serotonin-syndrome risks (5-HTP, L-tryptophan, SAMe, St John
Furosemide and supplements: interactions, cautions, and safe stacks
Furosemide (Lasix) and supplements: what to avoid (high-dose licorice), what to watch (potassium, hibiscus, dandelion, horsetail, uva ursi), and what
Hydrochlorothiazide and supplements: interactions, cautions, and safe stacks
Hydrochlorothiazide (HCTZ) and supplements: what to avoid (high-dose licorice), what to watch (calcium, vitamin D3, potassium, caffeine, hibiscus, St John
Prednisone and supplements: interactions, cautions, and safe stacks
Prednisone and supplements: what to avoid (echinacea, astragalus, high-dose licorice), what to watch (curcumin, berberine, St John
More medication × supplement pages coming. New drugs are added weekly from a rotation of the top-50 most-prescribed medications. How we build these pages →
All medication × supplement pages (5)
- Amlodipine and supplements: interactions, cautions, and safe stacks
- Gabapentin and supplements: interactions, cautions, and safe stacks
- Bupropion and supplements: interactions, cautions, and safe stacks
- Fluoxetine and supplements: interactions, cautions, and safe stacks
- Furosemide and supplements: interactions, cautions, and safe stacks
- Hydrochlorothiazide and supplements: interactions, cautions, and safe stacks
- Prednisone and supplements: interactions, cautions, and safe stacks
- Semaglutide and supplements: interactions, cautions, and safe stacks
- Sertraline and supplements: interactions, cautions, and safe stacks
- Tramadol and supplements: interactions, cautions, and safe stacks