Immunosuppressants
This is an educational list of interactions tied to a public source. It is not a complete medication review and it is not medical advice. Ask a pharmacist, or the clinician who prescribes the medicine, before you start, stop, or change a supplement. A pair that is missing here is not a safety clearance. SupplementScore takes no ads, sponsorships, or affiliate income. How this site is funded.
Medicines that suppress the immune system, including drugs that keep a transplanted organ from being rejected, are a bad place for guesswork. Two supplements have a cited note.
NCCIH names cyclosporine for St. John's wort. It does not give that same sentence for every immune-suppressing drug. The echinacea note is explicitly theoretical.
Names people search: Cyclosporine, and the broader group of immunosuppressants for the echinacea note
Do not combine on your own
NCCIH says St. John's wort can weaken cyclosporine, a drug used so the body does not reject a transplanted organ. A lower drug level can put the organ at risk. Do not start or stop this herb unless the transplant team has already told you what to do. NCCIH names cyclosporine. It does not give this same sentence for every other transplant drug.
Ask before you combine
NCCIH says there are theoretical reasons to suspect that echinacea might interact with immunosuppressants. The page also says evidence about liver-drug interactions is conflicting. "Theoretical" means this is not a proven case series. It is still the wrong herb to start on your own if you take a medicine meant to suppress the immune system. Ask the prescriber first.