Antibiotics

Supplements to separate from antibiotics

Talk to a pharmacist before you change anything.

This is an educational list of interactions tied to a public source. It is not a complete medication review and it is not medical advice. Ask a pharmacist, or the clinician who prescribes the medicine, before you start, stop, or change a supplement. A pair that is missing here is not a safety clearance. SupplementScore takes no ads, sponsorships, or affiliate income. How this site is funded.

Some antibiotics fail if a mineral binds them in the gut. The fix in the NIH fact sheets is to separate the doses, not to skip an antibiotic.

The quinolone examples named by NIH ODS include ciprofloxacin and moxifloxacin. The tetracycline examples include doxycycline. This page does not claim every antibiotic has the same interaction.

Last reviewed · Editorial team

Names people search: Ciprofloxacin (Cipro), moxifloxacin, doxycycline

Separate the doses

Separate the doses

Calcium can block quinolone antibiotics

NIH ODS says using calcium supplements at the same time as quinolone antibiotics, such as ciprofloxacin, gemifloxacin, and moxifloxacin, can reduce how much of the antibiotic you absorb. Taking the antibiotic 2 hours before or 2 hours after the calcium supplement prevents that effect. Finish the antibiotic. Do not stop it because you also take calcium.

CalciumCalcium carbonate or citrate

  1. NIH ODS, Calcium fact sheet for health professionals NIH ODS

Separate the doses

Magnesium can block tetracycline and quinolone antibiotics

NIH ODS says magnesium can form insoluble complexes with tetracyclines, such as doxycycline, and with quinolone antibiotics, such as ciprofloxacin and levofloxacin. Those antibiotics should be taken at least 2 hours before, or 4 to 6 hours after, a magnesium supplement. Separate the doses. Do not skip the antibiotic.

MagnesiumMagnesium glycinateMagnesium citrate

  1. NIH ODS, Magnesium fact sheet for health professionals NIH ODS

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