Wobenzym (systemic enzymes)
What it is
A combination of digestive enzymes and plant compounds used widely in European sports medicine. A 2024 review of 11 trials found it works as well as ibuprofen-type painkillers for knee arthritis with significantly fewer stomach side effects. Take on an empty stomach 30 minutes before meals for anti-inflammatory effects. Well tolerated overall.
Dose
2–3 tablets, three times daily (6–9 tablets/day total) on an empty stomach (≥30 min before meals or ≥2 hours after). Sustained use 4–8 weeks for inflammation outcomes.
Time of day & tips
Take on an empty stomach, 30 min before meals — food destroys the enzyme activity. Swallow whole with a large glass of water. Do not chew the tablets.
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