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Vitex / Chasteberry (Vitex agnus-castus)
PMS · Cycle regulation · Prolactin
Tier 2 — Promising
What it is
One of the best-studied herbs for PMS and menstrual cycle irregularity. The Schellenberg 2001 BMJ RCT (standardised Ze 440 extract) and the Ma 2014 meta-analysis found it significantly reduces PMS symptoms including breast pain, irritability, and mood swings. Works by modulating prolactin and dopamine. Takes 2 to 3 full menstrual cycles to see benefit. Do not use with hormonal contraceptives or fertility drugs.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
20–40 mg/day standardised extract (0.5% agnuside); allow 3 cycles for assessment
Time of day & tips
Take in the morning with water. Allow 3 full menstrual cycles before judging results. Avoid with hormonal contraceptives or fertility treatments.
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