SCORE

Vitamin K2 (MK-7)

Bone · Vascular calcification

Tier 2 — Promising

What it is

Directs calcium into bones and away from arteries, reducing calcification risk. The Rotterdam Study (4,807 people) linked higher dietary K2 intake to 57% fewer heart disease deaths — an observational association, not a supplement trial. Pairs synergistically with vitamin D3 for bone health. WARNING: directly antagonises warfarin — never take without medical supervision.

Efficacy

3/5

Safety

5/5

Research

3/5

Onset

1/5

Cost

3/5

Drug-int.

2/5

Dose

90–200 mcg/day MK-7 with fat, paired with Vitamin D3; AVOID if on warfarin without medical supervision

Time of day & tips

Take with a fat-containing meal (typically dinner) — fat increases absorption ~3×. Best taken alongside your Vitamin D3 dose. Avoid if on warfarin unless supervised by your doctor — K2 directly counteracts warfarin.

Compare or learn more

Compare with another supplement →
Browse by symptom →
Open the full interactive view →

Educational reference, not medical advice. About · Methodology · Privacy · Terms