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Vitamin B6 (P5P)

PMS · Pregnancy nausea · OCP support

Tier 2 — Promising

What it is

Effective for PMS symptoms and pregnancy nausea. A 2024 review confirmed significant PMS relief. FDA/ACOG recommend it for pregnancy nausea at 10–25 mg three times daily. Oral contraceptives deplete B6 levels. Use the active P5P form for better absorption and tolerability. Critical warning: doses above 100 mg/day long-term cause irreversible peripheral neuropathy (nerve damage).

Efficacy

3/5

Safety

3/5

Research

3/5

Onset

2/5

Cost

4/5

Drug-int.

4/5

Dose

25–50 mg/day P5P for PMS/OCP support. 10–25 mg × 3 daily for pregnancy nausea. NEVER exceed 100 mg/day long-term.

Time of day & tips

Take with food to reduce stomach upset. Never exceed 100 mg/day long-term — causes irreversible nerve damage. Can be taken morning or midday. Avoid very late evening doses.

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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