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Trimethylglycine (TMG / betaine anhydrous)
Methyl donor · Homocysteine · Performance
Tier 3 — Trending
What it is
Also known as betaine. Acts as a direct methyl donor in the methionine cycle, lowering elevated homocysteine. The performance literature (separate from the cardiovascular literature) shows small but consistent strength and power benefits at 2.5 g/day. Relevant for users on high-dose niacin or other methylation-depleting compounds. Generally well tolerated; very high doses can mildly raise LDL.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
4/5
Drug-int.
4/5
Dose
1.5–3 g/day for homocysteine; 2.5 g/day for performance endpoints
Time of day & tips
Take with food; pairs well with B12, B6, and folate for methylation support; monitor lipids if dosing >3 g/day long-term.
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