65
SCORE
Tributyrin / Butyrate
Gut barrier · Microbiome · Inflammation
Tier 2 — Promising
What it is
Butyrate is the main fuel source for the cells lining your colon and is critical for maintaining gut barrier health. The tributyrin form survives stomach acid better than sodium butyrate and releases butyrate directly in the colon. 2024 trials show improved gut lining integrity. Generally safe but can cause mild digestive changes initially.
Efficacy
3/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
300–600 mg/day tributyrin; or 2–4 g/day sodium butyrate
Time of day & tips
Take with meals. Start at the lower end of the dose range for 1–2 weeks. Sodium butyrate can have a strong odour — tributyrin capsules are odourless.
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