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Thiamine TTFD (sulbutiamine-related)
Active B1 · Cognition · Mitochondrial
Tier 3 — Trending
What it is
Tetrahydrofurfuryl disulfide form of thiamine (B1) — a fat-soluble derivative that crosses cell membranes more readily than standard water-soluble thiamine and reaches the brain. Distinct from sulbutiamine and from benfotiamine, with somewhat different tissue distribution. Older Japanese clinical literature is most extensive; modern Western trial evidence is thin. Sulphur-related odour after dosing is common.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
3/5
Dose
50–200 mg TTFD daily with food
Time of day & tips
Take with food; the sulphurous body-odour effect is harmless but noticeable; do not stack with other high-dose thiamine forms; not for use in pregnancy without specialist guidance.
Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.
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