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SCORE
Theacrine (TeaCrine)
Energy · Focus · Tolerance-free
Tier 2 — Promising
What it is
Provides clean energy similar to caffeine but without the tolerance buildup. 2024 trials found comparable energy and focus benefits with no tolerance even after 8 weeks of daily use. Unlike caffeine, it doesn't raise heart rate or blood pressure. Can be combined with caffeine for a stronger effect without jitters. Well tolerated in studies.
Efficacy
3/5
Safety
4/5
Research
2/5
Onset
4/5
Cost
3/5
Drug-int.
5/5
Dose
100–200 mg/day; can combine with caffeine for synergistic effect without jitters
Time of day & tips
Take in the morning or early afternoon with water. Avoid in the evening — may delay sleep. Can be taken with or without food.
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